Abstract: Due to the inconsistency between industrial demand and training direction, and inadequate abilities of engineering practice in grooming network and information security talents in colleges and universities, the construction of network and information security specialty cluster that integrates with multiple disciplines is put forward. Having analyzed the theoretical and technical requirements for talents in the backdrop of emerging engineering disciplines, this paper has not only initiated the industry-oriented theoretical curriculum system on network and information security specialty cluster, but also built the practical curriculum system that injects knowledge into experimental training. Moreover, the training model for innovative and entrepreneurial talents, along with relevant guarantees, is forged in the field of network and information security with distinct electronic information characteristics.