Abstract: Under the new situation of the development of innovation and entrepreneurship education, guided by the concept of omnidirectional talent training, the “team-based learning (TBL)” model was introduced into experimental teaching. Based on comprehensive experiments in university chemistry experiment textbooks, with student teams as the core, in the design of experimental schemes, experimental practices, and evaluation and summary of experimental schemes, this article adopts team-led and teacher-assisted strategies to comprehensively improve students’ organization, coordination, cooperation and innovative practical skills.