Abstract: In order to solve the problem that the traditional experimental teaching model can hardly meet the training of innovative talents, the application of “Taobao-style” teaching in the experimental teaching of engineering in colleges and universities is analyzed by taking the teaching reform practice of “Electronic System Design and Practice” in Xi’an Jiaotong University as an example. The reform practice shows that the experimental curriculum design of “Taobao-style” teaching is based on the students’ differentiated needs, clearly defines the “student-centered” teaching positioning, provides students with targeted and differentiated knowledge services, and helps stimulate students’ awareness of innovation and their ability to innovate. This teaching mode reform has achieved good results in practice, and has provided useful explorations for further optimizing the experimental teaching of engineering in colleges and universities and improving the training system for innovative talents.