Abstract: With the rise of science and technology level, the number, types and complexity of large-scale instruments in comprehensive universities are constantly changing. Promoting the sharing and contribution of large-scale instruments in universities through digital management, resource integration and policy support is an important means to develop the scientific research skills and social scientific and technological innovation. In this paper the remaining problems in the process of the sharing of large instruments in comprehensive universities are discussed. Taking the large-scale instrument sharing work of East China Normal University as a case, it expounds the positive effects of promotion personnel training, digital management and online technical consultation, and mainly puts forward the sustainable development strategy of instrument sharing service.