Abstract: Signal sampling is a key and challenging point in the teaching of the digital signal processing course. In response to the existing teaching issues, such as the lack of experimental components and the absence of training in higher-order thinking skills, the teaching reform and practice of signal sampling are carried out based on the principles of the outcome-based education (OBE) in the context of engineering accreditation. According to the connotation of the course objectives supported by signal sampling, the teaching content is restructured, comprising ‘mathematical description — mathematical modelling — model implementation — engineering application’. Online and offline teaching resources are developed based on ‘Mosoteach Software’ and ‘Pocket Lab’. A new theory-practice integration teaching model, ‘BOPPPS + Pocket Lab’, is implemented. The results indicate that the teaching is effective. Students demonstrate a deep understanding and application of signal sampling knowledge while also developing their higher-order thinking skills, such as modelling, analysis, and design.