Abstract: The implementation of the “Regulations on the Management of Administrative and Public Institutional State-Owned Assets” in 2021 has introduced new requirements for university state-owned asset management, explicitly mandating compliance with the principles of “safety and standardization, economy and efficiency, openness and transparency, and consistency of rights and responsibilities.” This paper explores the application of the Regulations in university state-owned asset management and analyzes the current challenges faced by university asset management, including shortcomings in asset preservation, the lack of a scientific link between asset allocation and performance evaluation, and conflicts between the roles of asset management personnel and internal control requirements. Based on this analysis, the article proposes optimizing asset management practices through the “Three Questions” concept (Is the asset there? Is it functioning well? Is it worth it?) and suggests optimizing the asset management system through deep integration of finance and assets, clarification of job functions, and strengthening of personnel allocation. It also proposes optimizing the business processes through standardized management and enhanced services, and initiating the construction of an asset performance evaluation system through the establishment of three major evaluation systems of “budget-asset,” “planning-asset,” and “talent-asset.” These measures contribute to enhancing the management level of university state-owned assets, ensuring the safe and efficient use of assets, supporting university teaching and research activities, and promoting the sustainable development of universities.