Abstract: With the application and development of nuclear science, the use of radioactive sources in teaching and research experiments in universities is constantly increasing. The safety of radioactive sources is an important part of the safety management of radioactive laboratories. As the primary storage facility for these sources, strengthening the library's physical and technical security measures is crucial for safety management. This paper mainly introduces the exploration and practice of the Nuclear Engineering and Nuclear Technology Laboratory at Sichuan University in constructing and safely managing a radioactive source library. By establishing a storage and monitoring platform, a dose monitoring and safety interlock system, and a source library security system, the laboratory has implemented a comprehensive “four-in-one” monitoring framework, which enables real-time online dose monitoring, remote video surveillance, intelligent inspection, and alarms for critical operational points. This approach has shifted the radioactive source control paradigm from a primary reliance on manual management to a technology-driven system. These practices can serve as a valuable reference for the construction and management of source libraries in other radioactive laboratories.