Abstract: At present, many universities and research institutions have established large-scale instrument equipment sharing platforms and their network management systems to facilitate the open sharing of large-scale instruments. However, in the actual operation process, how the network management system adapts to the actual situation of large-scale instrument sharing still faces many challenges. This article delves into the principles and framework for building intelligent large-scale instrument management systems, design architecture, module selection, and the construction of supporting systems. It also elaborates on the innovative attempts and active exploration of system optimization in the transition of instrument open sharing towards information management, providing practical experience for other universities in building and optimizing the management platform for large-scale instrument sharing networks.