Abstract: As an important renewable resource, the high-value utilization of biomass resources plays a crucial role in both teaching and research. The utilization of high-temperature and high-pressure equipment is essential for biomass valorization experiments in university laboratories. However, these devices may pose safety risks such as high temperature, high pressure and gas leak during operation. To comprehensively ensure the safety of personal, equipment, and property, the College of Biomass Science and Engineering of Sichuan University has implemented innovative management strategies for high-temperature and high-pressure equipment. These strategies include upgrading intelligent hardware, applying information management systems, establishing a multi-dimensional safety education system, especially the deploying of predictive maintenance and intelligent monitoring system based on big data analytics. These initiatives have significantly enhanced safety management standards of the high-temperature and high-pressure equipment and offer valuable practical experience for safety governance in academic laboratories.