Abstract: In the face of the new challenges of laboratory safety brought by the construction of new engineering, this paper innovatively constructs and practices the safety system model of “education-governance synergy drive”. The system takes information technology as the key support, constructs the comprehensive safety management information platform of intelligent laboratory of Chongqing University, and realizes the deep integration of safety education and safety governance. In terms of safety education, the integration of curriculum education, online learning and emergency drills has constructed a precise education system to promote the transformation of safety knowledge to safety ability training. In terms of security governance, a systematic governance framework covering the three-level responsibility system of “school-college-room”, intelligent security access, dynamic hierarchical classification management and closed-loop rectification mechanism is constructed, which realizes prevention first, controllable process and responsibility to people. Through the internal consciousness of education empowering personnel and strengthening the external constraints of the system, the safety status of the room is promoted from “passive response” to “active prevention.” The safety system model provides a visit to the construction of long-term mechanism for the standardization and scientificization of laboratory safety in colleges and universities.