Abstract: To address the challenges in current university laboratory management systems, such as poor multi-terminal compatibility, severe data silos, and weak scalability, this paper proposes an architectural approach for establishing a university-level laboratory management system based on RESTful WebAPI technology. The proposed solution adopts a layered microservices architecture (access layer/business layer/data layer), utilizes lightweight WebAPIs to connect various terminals (PCs, mobile terminals, and IoT devices), and achieves dynamic permission control through OAuth 2.0 and JWT technologies. Using WebAPIs as interfaces, a laboratory data hub is established to integrate data from university IoT devices, laboratory systems, academic affairs systems, personnel systems, asset systems, and other information systems, thereby enabling intelligent laboratory management.