Abstract: ​Large-scale scientific instruments in universities serve as critical resources for supporting research innovation and talent cultivation, yet their management and open-sharing capabilities remain relatively underdeveloped. This paper analyzes the prominent issues in the procurement evaluation, utilization efficiency, management models, resource sharing, operational maintenance mechanisms, and team development of such instruments in local universities. Based on the practical exploration and operational practice of the College of Biotechnology, Tianjin University of Science and Technology, we propose a systematic improvement pathway: establishing a centralized “1+N” integrated management system to achieve resource consolidation and optimized allocation; advancing intelligent construction centered on a digital platform and QR code-based “digital identity” to enhance service accessibility and teaching support capabilities; implementing a full-lifecycle fine-grained management system covering procurement, acceptance, operation, maintenance, and decommissioning; improving fee-based usage and preventive maintenance mechanisms to form a “self-sustaining” virtuous cycle; and strengthening professional technical team building to reinforce technical support and service effectiveness. Practical results demonstrate that these measures can effectively address challenges such as instrument idling, insufficient sharing, and extensive maintenance, significantly improving utilization efficiency and open-sharing capacity, thereby providing a replicable practical model for the high-quality management of large-scale instruments in local universities.