Abstract: This paper introduced the definition and significance of computational thinking. Aiming at the training objectives of Lu zhou Medical College, we analyzed the problems in the experiment teaching in the course of university computer foundation. Using computational thinking, the experimental reform and innovation methods were proposed, including the attention to the teaching idea, the increase of the design type, comprehensive experiment, hierarchical teaching, improvement of experiment evaluation system, etc. Thereby, this new teaching model will improve students computational thinking pattern,innovation consciousness and practical ability.