Abstract: Open laboratory is one of the important measures for higher vocational colleges to cultivate innovative talents in the new period and use teaching resources,which is also an important part of practice teaching reform. Through analyzing cause of the existing problems in the laboratory management,we put forward how to establish the open laboratory management system continuously, and improve the operational mechanism of laboratory safety. Perfecting the management system is an important guarantee for the safe operation of the laboratory, and it has a profound significance to improve the teaching ability of teachers’ scientific research ability and cultivate students’ innovation ability.