Abstract: The content of signals and systems course cover time domain and three transformation domains. The course has distinct engineering background and relates to rich mathematics. Because the course contains deep professional connotation, practice teaching should be closed to theoretical content and engineering background, teaching method and content should be reformed. In this paper, the practice teaching mode of signals and systems was re-designed, including experiment content, experimental teaching method, experimental scheme, curriculum design and examination method. The proposed experimental teaching method had been carried out in two majority and made great impacts.