Abstract: With the development of modern manufacturing industry, enterprises of products from concept design to design product level, component level requirements are also increasing. As an important course, Pro/E(Creo) is a very practical and application, it is difficult to let students feel great advantage brought by the reform and to stimulate students’ interest in learning with the traditional teaching mode and the old software system. From the cultivation of high level of design talent, this paper analyzes the current existing deficiency in the Pro/E(Creo) teaching, puts forward some improvement measures to meet the need of society, and to think and discusses the course teaching reform of Pro/E(Creo).