Abstract: The innovation of teaching mode is an important method to improve the quality of college classroom teaching.The inquiry-based small-class teaching in universities is a new teaching mode.The paper firstly analyzes the four main problems involved in the teaching mode.It introduces a kind of cooperative small class teaching mode,which is very suitable for the teachers who carry out the large-class teaching in the same course to carry out the seminar “small class teaching”.The teaching mode is very suitable for the needs of a small class students for the classmates.Practice shows that the teaching model in the actual teaching has achieved good teaching results.