Abstract: In this paper,the problems in the traditional experimental teaching of marine biology were analyzed to explore the project teaching model.According to the scientific research advantage of marine biology in our school and combination of comprehensive experimental teaching and scientific research projects,three teaching modules were explored to study the project the teaching mode,such as before class (application)-class (operation)-after class (reply).Through the survey and feedback to students,based on the professional comprehensive experiment under the project teaching mode,students’ interest in learning can be stimulated.Furthermore,students have the opportunity to analyze problems and solve problems,which can improve their innovative and practical ability.The results will provide a theoretical reference on the training of talents for local colleges and universities under the background of transformation and development.