Abstract: In order to explore the corresponding measures of Pharmaceutical laboratory reagents and drug safety management,to ensure the safe,orderly and effective conduct of pharmaceutical experiment traing.This article uses a case-study method,combined with the teaching of natural medicine chemistry course “Extraction,Separation and Identification of Rutin from Sophora japonica” experiment to study the drug reagent management initiatives.Practice has proved that through the pharmacy laboratory pharmaceutical reagents and drug management innovations included risk assessment standards,supervision mechanism,safety education content,experiment teaching evaluation,etc.Through the pre-risk management and control,risk monitoring in events,risk-based prosecution after the omni-directional management to ensure the safe and orderly pharmacy experiment teaching.