Abstract: According to the current practice teaching in colleges and universities should be closely linked with technical hotspots,and for the requirements of social application services,a single-chip microcomputer curriculum design based on human-computer interaction of bio-electricity was launched.Firstly,this paper elaborates the implementation basis of curriculum design,and focuses on the analysis of the common characteristics of selection of the subject-comprehensive practicality,feasibility and novelty.Then the implementation of the curriculum design to implement the idea to guide the excitation,timely guidance,evaluation and assessment were explained.Finally,the human-computer interaction control system based on the surface EMG signal is specifically described as a case.