Abstract: to the content of Food Safety and Detection experiment courses multi-knowledge points,strong applicability,and involving complicate experimental methods and other special characteristics.Thus,establish a new type of online-offline mixed experimental teaching model,which achieves the purpose of comprehensive application of multi-knowledge and multi-experimental skills.It is also relives pressures such as the number of hours of experiment classes,lack of venues and instruments.It is a new experimental teaching model which is beneficial to the cultivation of innovative talents with high quality in pharmaceutical science.