Abstract: Innovation and entrepreneurship education of college has become an important content of higher education teaching reform in China. The innovation and entrepreneurship education of college students through the platform of experimental teaching center of biological sciences is explored. Firstly, it needs to strengthen the concept of innovation and entrepreneurship education and to optimize the training model for innovative and entrepreneurial talents. Secondly, the innovative practical teaching system is optimized through reforming the experimental teaching content. Thirdly, an open and diversified education ecosystem for innovation and entrepreneurship is built up by strengthening the open management of biological laboratories. Finally, attention should be paid to innovation and entrepreneurship education, practical guidance to create a good atmosphere for innovation and entrepreneurship, and creating a new system for innovation and entrepreneurship of biological science.