Abstract: The microprocessor practice course requires students to use MSP430 microprocessor as the core to carry out comprehensive design and development of software and hardware and complete course project production. Curriculum reform takes engineering education professional accreditation as the background and education output as the guidance, and explores from the curriculum outline and continuous improvement mechanism. The syllabus mainly clarified the purpose of experimental teaching, adjusted the content of experimental teaching and reasonably quantified the evaluation standards of experimental results, and increased the examination of students’ software and hardware design, on-site acceptance of works, and video work demonstration. After five years of practice, the microprocessor practice curriculum reform has effectively stimulated students’ interest in learning, cultivated students’ ability to solve related engineering problems and teamwork spirit, and has achieved remarkable teaching results.