Abstract: By introducing the project-based teaching method combining virtual simulation and real practice, this paper summarized the role of such a method in promoting the concept of innovative textile design, increasing learning enthusiasm and interest, and improving team spirit and organization and coordination ability. It also put forward the mode and method of project-based practical teaching of combining virtual simulation with real practice in the teaching of innovative textile design, which was implemented in stages. Teachers give guidance in stages, guide students to conduct virtual simulation and real creation, and complete the project-based curriculum. Taking the curriculum design practice of students enrolled in 2015 who major in textile engineering as an example, the results showed that compared with previous design works, the students of this year have shown higher product creativity, practical ability, and participation.