Abstract: To allow mechanical manufacturing and automation majors to grasp the disciplinary integration of machinery, control and communication technologies, an comprehensive experiment was designed based on abundant research and experiment. This experiment takes practical problems as the theme and adopts the format of students design and production supported by teachers’ guidance, with an emphasis on the integration of engineering and design, the cultivation of active learning and practical ability, and the use of both online and offline learning methods. This course integrates multi-disciplinary knowledge, adopts hands-on experiments, heuristic learning, failure analysis and other methods to teach students how to integrate and apply multi-disciplinary knowledge and gradually improve their comprehensive ability and problem-solving ability in handling practical engineering problems.