Abstract: Under the background of education informatization, the application of WeChat public platform in teaching has attracted more attention. In this paper, a WeChat public account was established with an aim to provide instructions on the use of large-scale instruments, and demonstrate large-scale laboratory instruments on students’ mobile phones. The Rain Classroom teaching model based on WeChat and PowerPoint was introduced. We established an integrated model of instrument use service and instrumental analysis experiment teaching on WeChat public platform. It has promoted the deep integration between mobile information technology and instrumental analysis experimental teaching, and explored the practice of reforming the instrumental experiment teaching method and the innovation of talent training model through modern mobile information technology.