Abstract: In view of the difficulties in the safety management of university chemical laboratory, a chemical safety supervision platform is built to realize the “closed-loop” fine management of chemicals. Given the characteristics of virtual simulation experience, a smart safety access platform of chemical laboratory that incorporates safety education resources, safety test, safety access certification, safety management and other functions is also established to explore the learning process and operation management mechanism of laboratory safety access platform. The construction and implementation of the safety system of chemical laboratory help eliminate the hidden dangers of chemicals, enhance the safety responsibility consciousness of students, reduce the occurrence of safety accidents, and guarantee the safety of chemical laboratory.