Abstract: The management of hazardous chemicals in colleges and universities is the focus and difficult point of laboratory safety management. In order to strengthen the construction of hazardous chemicals safety management systems in local normal universities, this paper sorts out the existing problems and difficulties on the basis of investigating the current situation of hazardous chemicals management in local normal universities. Combined with the practice of hazardous chemicals management, suggestions and countermeasures are put forward from the aspects of system construction, hardware construction, safety education and training, and hazardous waste disposal, to promote local normal universities to supplement their shortcomings and strengthen the safety management of hazardous chemicals.