Abstract: Under the background of new engineering education, in order to conduct interdisciplinary-integrated practice teaching reform, this paper takes the curriculum design and comprehensive experiment of a new discipline named aircraft control and information engineering in Beihang University as an example, and incorporates several disciplines such as aircraft, control and information processing from the perspectives of three-dimensional experimental system, comprehensive syllabus and intelligent practice platform. By designing comprehensive experiment project based on diverse research direction, this paper combines the algorithm design in traditional teaching practice and intelligent innovation practice platform, which enables universities to carry out teaching activities that keep pace with the most update trend of technology development. In addition, it helps cultivate the students’ systematic thinking, design thinking, and engineering thinking, and promote their practical innovation ability.