Abstract: With the development of smart phone, Internet and cloud storage technology, all trajectories of people and objects can be recorded. Big data concept, widely used in Internet services, propels the reform of laboratory equipment management model in universities. This paper reviews the status quo of laboratory equipment management in China’s universities, timely analyzes the existing problems, and elaborates the necessity and urgency of dynamic management of equipment. Based on the development of the laboratories in double first class universities, this paper puts forward the basic principles and construction ideas of dynamic management system of laboratory equipment in universities.