Abstract: An exploration of teaching approach reform in the fluid mechanics course of Sichuan University is introduced in this paper, taking the teaching practice of the Bernoulli equation in fluid mechanics as an example. The teaching reform practice shows that this multi-way integrated teaching approach integrates the project-based teaching into the assessment of the whole process, and adopts a variety of approaches including “learning, practicing, testing and application” and the integration of teaching resources, especially self-motivated experiments and application practices, to promote students’ enthusiasm and active participation in learning, helping them to improve their practical and innovative abilities. The teaching reform which is oriented to the requirements of the establishment of China’s new engineering disciplines, highlights the learning-centered educational philosophy, and has achieved good results in its application, providing a useful exploration for further optimizing the project-based teaching and improving the implementation of the whole process evaluation.