Abstract: In view of the facts in universities for nationalities and the teaching requirements of chemical experiments, a step-wise open experiment teaching model is explored to improve the core literacy of students. Multiple measures including setting up online course resources, optional experimental course, and skill trainings are adopted to construct the step-wise & multilevel open experiment teaching system at entry level, universal level and advanced level. The practice indicates that the implementation of this new model can effectively improve scientific literacy, knowledge level, manipulative ability and innovation ability of students, extensively activate their critical thinking, and provide a new way for cultivating innovative talents of the universities for nationalities.