Abstract: The insufficient integration practice is the main cause of the current difficulties in the cultivation of compound talents, such as the lack of cross-disciplinary integration application skills and the weak ability of scientific research innovation. The project-based teaching, originated from the pragmatic teaching concept of “learning by doing”, is highly interdisciplinary and practical, and provides an effective way for the cultivation of compound talents. Based on the cultivation of interdisciplinary talents under the emerging engineering education, this paper constructs an advanced project-based practical teaching system for e-commerce majors, so as to shape the students’ compound knowledge structure of “technology + management” and improve their interdisciplinary innovative thinking and ability of “engineering + business”.