Abstract: Taking the microprocessor MSP430F6638 as the control core, a set of fully differential RF wideband numerical control gain amplification system is designed and implemented. The system includes five modules, including input conditioning, programmable gain amplification, output, control and system power supply, which is able to achieve wideband amplification in the range of 30 to 240 MHz. The system is subjected to strict impedance control and shielding to effectively reduce the interference of signal reflection and environmental noise, and the fluctuation is less than 2 dB in 40 to 200 MHz. The system gain drops by more than 30 dB at 20 MHz and 270 MHz, and any step can be adjusted within the gain range of 0 to 64 dB, with a minimum step of 1 dB. The paper analyzes the four circuit types of the fully differential amplifier, introduces the advantages and disadvantages of several commonly used filters, and renders the specific circuit diagram of the core module. The experimental data is combined to make a complete analysis of system performance, providing convenience for application in various occasions such as subject competition and engineering practice.