Abstract: The fourth wave of the industrial revolution has swept up, driving higher education to make changes and adjustments. The single and rigid practical teaching model in the past is no longer suitable for the training of engineering and technical talents in colleges and universities under the background of the new engineering. In order to adapt to this major change, taking the innovation and transformation of the integrated experimental system platform for the major of measurement and control specialty as an example, a completely open self-organizing integrated experimental system platform is proposed based on the analysis of the original modular large-scale integrated experimental platform structure. It has changed the rigid structure of the past, and can be independently developed by students according to their needs, creating good hardware conditions for the cultivation of students’ independent innovation ability and engineering ability.