Abstract: In order to solve the problem of large investment in experimental teaching equipment and the impracticability of experiments due to inaccessible, invisible, and risky petroleum industry production, the petroleum engineering major has carried out a syncretic top-level design of virtual simulation technology and experimental courses. Combining professional characteristics, discipline characteristics, curriculum characteristics and talent training characteristics, this paper selects important links in the process of oil and gas production, drilling engineering, well control operation, oil and gas gathering and transportation, and oil and gas safety production, and conducts modular, personalized and practical design and secondary development of the virtual simulation technology platform. Meanwhile, with the help of information technology, an information-applied evaluation system is set up. Through two-way construction, virtual simulation technology is no longer an auxiliary means and tool for experimental teaching, but a brand-new way to connect students with laboratories, production sites, equipment and experimental training content, stimulating students to learn professionally, improving students' interest in analyzing and solving complex engineering problems and achieving the goal of cultivating high-level applied technology talents.