Abstract: Experimental teaching plays an important role in cultivating students’ knowledge, ability and quality. However, the experiment teaching of current stage falls into a dilemma due to the limitation of experiment time and space. “Internet + education” is breaking the limitation of time and space of traditional education and provides a new way for the reform, innovative development of experimental teaching and the transformation of experimental teaching model. Under the condition that the space and time of experimental teaching do not increase, a novel hybrid experimental teaching model is proposed, by which the online experiment microlecture presents teachers’ demonstration and explanation of basic experimental knowledge, instrument and operation process. At the same time, the experimental scheme design and feasibility demonstration based on virtual simulation experiment are carried out, the organic integration of online and offline course experimental teaching is conducted, and the functions of both consolidating theoretical knowledge (confirmatory experiment), and training problem-solving skills, innovation ability (design experiment) can be realized in experimental teaching. The novel model not only makes it possible to set up designed experiments in the situation that the space and time of the existing experiment teaching site approaching the limit, but also provides a new approach for course experimental teaching model changed from the teacher-centered to the student-centered. It is proved by the course experimental teaching practice of “Exchangeability and Measurement Technology” that the hybrid experimental teaching model could promote the course experimental teaching effect.