Abstract: Given new problems encountered in the comprehensive experiment reform of “mechanical design base”, this paper takes the experimental teaching of mechanical design base as the example, and explores a information-applied management method for comprehensive experimental teaching under “new engineering”. This paper introduces the “microprogram” of WeChat into the information-applied management of experimental teaching, and puts forward a management method for comprehensive experimental teaching under “new engineering” revolving around four aspects, namely “Wechat” safety education of laboratory, “WeChat” record of laboratory, “Wechat” experimental teaching management and “WeChat” online teaching. In addition, the method is applied in mechanical design base laboratory of Xi’an Jiaotong University.