Abstract: In response to the demand of cultivating the innovation-applied single chip microcomputer talents and the teaching characteristics of single chip microcomputer practice courses, this paper, guided by cultivating students' knowledge, ability and quality engineering capabilities, sets up a practice teaching system of single chip microcomputer revolving on the students. Relying on the existing experimental teaching resources of the college, experimental teaching contents are optimized, experimental teaching projects are innovated, and the knowledge goals of cultivating engineering ability are achieved. The “research, design, implementation and report” four links and the teaching model of “concentrating in class and opening style after class” are practiced to improve training operation technology and practical ability. A diversified evaluation method is established to enhance the students' sense of achievement and improve their quality. The combination of in-class teaching practice and extracurricular competition can promote the balanced and comprehensive development of students in the three dimensions of knowledge, ability and quality. The practice shows that the implementation effect of single chip microcomputer experimental teaching system is obvious, which can improve students’ innovative thinking and engineering practice ability of knowledge, ability and quality, and meet the needs of the state and society for the cultivation of single chip microcomputer talents.