Abstract: Due to the high usage rate and large staff mobility in laboratories in universities and colleges, several problems such as the unreasonable layout of laboratory space, inadequate inspection of laboratory equipment, low laboratory operation efficiency, and hidden dangers in laboratory safety management, would emerge during the site management. Starting from the common problems in laboratories, the seven elements (sort out, set in order, shine, standardize, sustain, safety, saving) of “7S” management are applied to the laboratory equipment and material management, personnel management and environmental management of experimental sites. Meanwhile, three safeguard measures, which are the organization, system, publicity and education, are carried out in the“7S” management in the laboratories. Finally, the application effect of the “7S” management in the laboratory of the College of Urban and Rural Construction of Shanxi Agricultural University is presented, to provide some references for the laboratory construction in other universities and colleges in site management.