Abstract: The comprehensive experiment about product innovative design and manufacturing is designed and carried out for the mechanical specialty. Based on projects, the experiment integrates five tasks in the field of reverse engineering: data acquisition and processing, reverse reconstruction, innovative design and manufacture, detection. The experiment is comprehensive, advanced, innovative and expansible, and it can be used as a comprehensive practice project for graduation, or as an open experiment for students to conduct the second classroom. Verified by practical teaching, the experiment can not only consolidate students’ understanding of the basic theory and process of reverse engineering, enhance students’ practical ability and innovative thinking ability, but also improve students’ comprehensive application ability of design and manufacturing.