Abstract: Large scale instruments and equipment are important and necessary scientific and technological resources in modern universities. Building an open and sharing platform for large-scale instruments and equipment is an effective way to improve the efficiency of university resource utilization and promote collaborative development. With the deepening of the platform construction of universities and the widening of sharing service coverage, the limitations of single entity instrument platform are increasingly apparent. It is necessary to integrate the scientific and technological resources of universities in the region and establish a higher level of open sharing system. Based on the summary of the existing regional opening and sharing measures of university equipment and the accumulation of relevant experience, this paper put forward some suggestions based on the construction and effective operation of interschool equipment sharing platform, and probed into the new ideas of mutual benefit and collaborative innovation.