Abstract: The laboratory in university is an important base to carry out experimental teaching, carry out scientific research, cultivate students’ innovative ability and improve their comprehensive quality. With the continuous advance of educational informatization, the opening and sharing of laboratory resources have become an urgent need for the development of colleges and universities. Given the main problems existing in the opening and sharing of laboratories at present, combined with the laboratory work practice of Hangzhou Dianzi University, this paper puts forward the university laboratory management system based on resource sharing from the aspects of management system, overall plan, resource allocation, digital management, and team construction, to provide more effective, convenient, and humanized resource sharing services for the universities and the society.