Abstract: The “trinity, multi-measures” automation laboratory safety construction scheme and path are put forward, combining with strong engineering characteristics, information technology and the concept of education in the new era. Taking informatization construction, laboratory platform construction and the practice curriculum system construction as the main body, with the help of “Internet +”, intelligent monitoring platform, website measures to carry out the informatization construction, building a “top-down” accurate, executable, effective laboratory platform, constructing a “safe closed-loop” practice curriculum system based on the concept of results-based education. Combining with the practice results of the automation experimental teaching center in our school, we consider the improvement direction and construction points of laboratory safety construction, which aims to lay a solid foundation for laboratory safety construction and provide intentional reference.