Abstract: In order to strengthen students' understanding of nonlinear problems, a set of hysteresis nonlinear hardware-in-the-loop simulation platform for piezoelectric ceramic nanopositioners based on dSPACE is designed. Firstly, the composition of the experimental platform is introduced in detail. Secondly, the hysteresis nonlinear data of the piezo-positioner is collected based on the experimental platform, the PI (Prandtl-Ishlinskii) model is obtained by the general least squares identification method, and the PI inverse model is obtained by the analytical method. Finally, the PI inverse model is added to the feedforward path to offset the hysteresis nonlinearity, thereby transforming the nonlinear system into a pseudo-linear system. During the experiment, students can not only deepen their understanding of the nonlinear characteristics and inverse system method, but also effectively solve the hysteretic nonlinear problem of a kind of intelligent materials through the parameter identification method and inverse compensation method, improve students’ ability to combine theoretical knowledge with engineering practice, and cultivate automation students’ ability to solve complex engineering problems.