Abstract: Laboratory safety is an important guarantee for teaching and scientific research. Based on the background that the safety environment of laboratory teaching and scientific research in the construction of “Double First-class” and “New Engineering Disciplines” is becoming more and more complex, this paper explores the agile collaborative development mode of university laboratory safety management system. Rely on the State Key Laboratory of Mechanical Transmission of Chongqing University, the safety education management module, safety inspection management module, laboratory site management module and experiment appointment management module are developed based on “DingTalk + H3Yun” platform. It improves the technical level of laboratory safety management and ensures the safe operation of scientific research experiments. It can be used as reference for other universities to quickly develop laboratory safety management system.