Abstract: In order to meet the teaching and research needs of biology, chemistry and pharmacy students in the extraction and activity research of plant natural products, a comprehensive virtual simulation experiment project on the study of liver-protective activity and chemical composition of Tibetan medicine Veronica ciliata Fisch is designed using the WebGL technology, 3D simulation technology and development tools such as Unity3D, Maya and Visual Studio. This project is based on the extraction and activity research of natural product in plants, closely following the knowledge of theoretical courses and real experiments and absorbing the latest scientific research results and application cases as well. Teaching practice of this project shows that the virtual training is a good way to enhance of ability of students to learn the principles and key skills in the experimental teaching. It is indicated that the virtual simulation experiment effectively expands the cognitive scope and learning space of students, creates a “virtual-real, virtual-real complementary” practical teaching mode, enables students to participate in comprehensive experimental teaching independently and deeply, and improves the ability of independent learning, innovation and comprehensive practice of students.