Abstract: As a laboratory platform for public scientific research and teaching services, the analytical and testing center has the characteristics of large personnel flow, large amount of testing and high security risk. The security management of center is crucial to the stability of school and society. Based on the standards and requirements in CMA (China Mandatory Approval) certification, and relying on the sharing platform of large instruments and equipment in universities, a series of work has been carried out around laboratory safety management mechanism, laboratory standardization work, safety education and access system. In this way, the safety management system of the analytical and testing center is optimized, and the stable and efficient operation of the laboratory is ensured, which provide references for construction of laboratory safety.