Abstract: The university laboratory is an important place to carry out scientific research and personnel training, but in recent years, the frequent safety accidents in the laboratory have brought adverse effects on the normal teaching and research work. How to effectively manage experimental safety is a problem that needs to be considered and solved. A set of laboratory intelligent monitoring and management system is designed, which can realize the intelligent monitoring and safety management of the laboratory environment all day long. The system is divided into upper computer and lower computer. The upper computer installed in the office or other places can remotely monitor various environmental parameters of the laboratory and control the environmental equipment of the laboratory. The lower computer installed in the laboratory can collect various environmental parameters of the laboratory in real time and connect the environmental equipment of the laboratory. This system uses ARM based chip as the main chip, and selects a series of suitable sensors to collect environmental parameters, including carbon monoxide sensor, carbon dioxide sensor, temperature and humidity sensors, water leakage alarm controller, etc. The system has been put into trial use in Hubei Electrical and Electronic Experiment Teaching Demonstration Center of Central China Normal University. During the trial period, it runs normally and brings great convenience to the management of the laboratory.