Abstract: In the teaching of undergraduate mechanical-manufacturing-technology-related courses, considering the danger environment and the process complexity of the large equipment manufacturing, it is quite difficult for students to carry out physical experiments in the physical laboratory or physical intelligent manufacturing workshop, which greatly limits the improvement of students’ engineering practice ability. On this basis, a virtual production workshop as well as the virtual simulation experiment teaching method for the courses group of mechanical manufacturing is proposed. Through the WebGL technology standard, the interactive operation of the turbine engine impeller automatic processing virtual workshop is established, and furthermore the virtual-actual combined interface corresponding to experimental equipment such as the physical computer numerical control (CNC) machine tool, manipulator, and automated guided vehicle (AGV) transportation cart as well as the virtual simulation experiment teaching software are developed for practical teaching. The relevant results have been applied to the teaching of mechanical manufacturing courses, and the results show that the students’ professional knowledge level and engineering application ability have been significantly improved, and the satisfied teaching effect proves the rationality and practicability of the practical teaching measure.